The President’s speech at the closing ceremony of the IUPS World Congress in 2013 highlights the expansion of the International Union of Physiological Sciences, and the return of physiology to fulfil the prediction of James Black (Nobel Laureate 1988) that it would be the means by which molecular biology and the genome would be interpreted to understand the Logic of Life. The spectacular introductory fanfare was that used at the Congress, with thanks to The Physiological Society, and The Refinery.