Department of Physiology, Seoul National University College of Medicine
ACADEMIC POSITION:
Associate Professor, Cardiovascular & Ion Channel Signaling
Laboratory, Department of Physiology, Seoul National University, College
of Medicine
RESEARCH INTERESTS:
Our research team aims to identify mechanisms leading to the
pathogenesis of cardiac diseases (heart failure, sudden cardiac death,
atrial fibrillation), hoping to provide novel therapeutic strategies to
prevent and cure heart diseases. In particular, we are focusing on
nitric oxide and reactive oxygen species signalling in the regulation of
ion channels, Ca2+ handling proteins, myofilament proteins and cardiac
contractile function. In addition, we are trying to understand free
fatty acids and cardiac metabolism and their interplay with Ca2+
handlings in the regulation of cardiac function in healthy and diseased
hearts. Furthermore, we will to expend our research on exercise and the
protective mechanisms for cardiovascular diseases. Currently we use
hypertension, atrial fibrillation, transverse aortic
constriction-induced heart failure models.
Essential techniques include: sarcomere/cell length and real time Ca2+ fluorescent measurements, patch-clamp techniques in single isolated myocytes, immunoblotting & co-immunoprecipitation, confocal microscopy, real time RT-PCR. We also conduct Metabolomics and Proteomics through collaboration.